Why did the Indians who profited from the fur trade turn to the tragedy of being slaughtered instead?

Why did the Indians who profited from the fur trade turn to the tragedy of being slaughtered instead?
The term "Indian" is not a term for a nation, but a general term for all the indigenous peoples of the American continent except the Inuit.

strictly speaking, the term "Indian" is not a term for a nation, but a general term for all the indigenous peoples of the American continent except the Inuit, including, but not limited to, the Mayans, Aztecs, Incas, and so on.

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